biochemistry

K Students Win Battle of Chem Clubs

Posted on

Congratulations to the seven Kalamazoo College Chemistry Club members who won the annual Battle of the Chem Clubs last weekend at Michigan State University. Bri Leddy, Audrey Thomas, Chris Vennard, Liz Knox, Maria Fujii, Jake Sypniewski and Adam Decker competed in four rounds of chemistry trivia and laboratory-based games before taking on Hope and Olivet in the playoffs, which consisted of a speed titration and a Winter Olympics-themed race.

Battle of the Chem Clubs team
Bri Leddy, Audrey Thomas, Chris Vennard, Liz Knox, Maria Fujii, Jake Sypniewski and Adam Decker represented Kalamazoo College in the Battle of the Chem Clubs at Michigan State University.

Twelve teams from Michigan including Michigan State, Aquinas, Wayne State and the University of Michigan-Flint participated along with the University of Toledo. The schools were not separated into size or public and private divisions, meaning the title was an overall championship. K’s representatives also finished with the fastest and most accurate speed titration, winning an award for that, too.

“We’re excited that we beat such tough competitors from both rival schools and large institutions,” Thomas said. “We showed we, as a small college, could hold our own against the best in the state. It’s nice to bring home a win, too, because it helps showcase our fantastic chemistry department in a good light to prospective majors.”

HERS Institute Selects K Associate Provost for Cohort

Posted on

Kalamazoo College Associate Provost Laura Lowe Furge is one of 65 women leaders from across the country who has been selected to attend the 2018 Higher Education Resource Services (HERS) Institute. Furge will be a part of the University of Denver cohort that meets from June 18-30.

Laura Lowe Furge HERS Institute
Furge, who is also a professor of chemistry, was one of just six HERS attendees awarded a Clare Boothe Luce (CBL) Scholarship, which provides full tuition, accommodations, meals and travel to women in STEM higher education to attend the HERS Institute.

The HERS Institute will support and encourage women as they develop strategies for their leadership roles and establish communities including peer-and-mentor connections. Working together, they can thrive in and shape a new environment for equality and excellence in higher education.

Furge, who is also a professor of chemistry, was one of just six HERS attendees awarded a Clare Boothe Luce (CBL) Scholarship, which provides full tuition, accommodations, meals and travel to women in STEM higher education to attend the Institute.

For more information on the HERS Institute, visit its website.

International Chemistry Magazine Publishes K Grad’s Research

Posted on

A 2017 Kalamazoo College graduate has been published in Angewandte Chemie, a German international chemistry magazine, for his senior individualized project (SIP) involving how prescription medications interact with the human body.

John Bailey presents his research published in an international chemistry magazine
John Bailey ’17 presents research related to his senior individualized project.

John Bailey, who was a chemistry major and math minor from Midland, Mich., performed research through a group at Michigan State University focusing on aromaticity. The term describes a ring-shaped molecule that exhibits more stability than other connective arrangements with the same atoms.

The research and resulting chemistry magazine article highlights how stability involving aromaticity could allow a greater range of choices in a pharmaceutical’s design, maximizing the drug’s effect in a targeted human system without harming other systems in a patient’s body.

The article, titled “High-Field NMR Spectroscopy Reveals Aromaticity-Modulated Hydrogen Bonding (AMHB) in Heterocycle,” has no immediate effect on how drugs are formulated or prescribed. Still, the results could one day have strong clinical implications for treatment courses such as chemotherapy. As a result, the research doesn’t stand to make Bailey famous, but a positive advancement in medicine one day will have been the result of many people like Bailey collaborating and building on each other’s work.

“It feels good to have work I’ve done out there that could be helpful to other humans,” he said.

Bailey is in Kalamazoo for at least an additional year, but would eventually like to attend graduate school and end up professionally as a leader in a research lab. He credits Chemistry Professor Jeffrey Bartz and Math Professor Eric Barth for giving him the guidance and encouragement he needed to succeed with his SIP.

“Hopefully, I will have enough knowledge I can be an effective member of my community professionally and nonprofessionally,” Bailey said. “I think K did a good job letting me understand how big a place the world is and how much I need to be humble. I want to keep working hard because no one is ever done growing.”

 

K Students’ Research Relevant to Prescription Drug Discovery

Posted on

Four Kalamazoo College chemistry students from Professor Laura Furge’s lab attended the Great Lakes Drug Metabolism and Disposition Discussion Group annual meeting on May 4 and 5 in Kalamazoo. The entourage included three – Sarah Glass ’17, Christi Cho ’17 and Cydney Martell ’19 – who presented their research regarding enzymes that help the human body interact with and process prescription drugs. Their research is relevant to prescription drug discovery and treating diseases, especially in predicting how individuals will respond to their medications.

Student Research Relevant to Prescription Drug Discovery
Cydney Martell ’19 is one of three students who presented their research regarding enzymes that help the human body interact with and process prescription drugs at the the Great Lakes Drug Metabolism and Disposition Discussion Group annual meeting. Their research is relevant to prescription drug discovery and treating diseases, especially in predicting how individuals will respond to their medications.

Cho – a chemistry major from Anchorage, Alaska – says her studies could help advance clinical research that ensures drugs won’t build up to toxic levels or negatively interact with other prescription drugs. She will attend the University of Washington as a graduate student starting this fall, where she has received a Graduate School Top Scholar Award to help fund her education. Yet K has made an impression on her.

“The faculty make a really good effort to create a friendly learning environment,” Cho said. “Chemistry be challenging at times. They try to bring the fun into every aspect of it.”

Glass – from Shelbyville, Mich. – in addition to presenting research, organized and planned the event’s luncheon, providing students, graduate students, post-doctoral fellows and pharmaceutical industry representatives with networking opportunities. Glass majored in chemistry at K, minored in math with a biochemistry concentration, and finished her undergraduate studies in December after just 3 1/3 years. She will start pursuing a Ph.D. at Vanderbilt University this fall.

At K, “all the chemistry faculty are extremely helpful and knowledgeable,” Glass said. “Students get a lot of hands-on experience through labs and have opportunities to get involved in research early on.”

Martell – a chemistry major from Gull Lake, Mich. – plans to further her research in K labs this summer.

“For me the annual meeting was a great experience to see how the topics I have learned in biochemistry and through research can be used to understand and critically think about current research in industry and academia.” Martell plans to attend graduate school after K, where she will earn a Ph.D. She is leaning toward teaching research in her professional career.

K chemistry major and Furge lab research associate Sabrina Leddy ’19 also attended the meeting. K Visiting Professor Kyle Furge took the 13 students from his advanced biochemistry course to the meeting’s opening plenary.

The Great Lakes Drug Metabolism and Disposition Group website says the group:

  • provides opportunities for graduate students, postdoctoral fellows and senior-level associates from regional universities to meet pharmaceutical scientists and pharmacologists from various academic and industrial backgrounds;
  • promotes regional visibility of the discipline of drug metabolism and disposition science;
  • facilitates informal dialogue between pharmaceutical partners and academic laboratories; and
  • enriches interdisciplinary collaboration opportunities for those interested in drug metabolism and disposition.

7 K Students Attend Experimental Biology, 2 Honored

Posted on

Seven Kalamazoo College students attended the annual Experimental Biology meeting in Chicago in May including two honored in the event’s undergraduate research posters competition.

Experimental Biology Posters Competition
K students Raoul Wadhwa (second from left) and Sarah Glass (second from right) received honors in the Experimental Biology undergraduate research posters competition. They are joined by professors Regina Stevens-Truss and Laura Furge.

About 225 undergraduates from across the country participated in Experimental Biology’s poster competition in the categories of:

  • proteins and enzymes;
  • metabolism, bioenergetics, lipids and signal transduction;
  • DNA, RNA, chromosomes and gene regulation; and
  • cell and developmental biology.

Sarah Glass ’17, of Shelbyville, Mich., was awarded first place in the “proteins and enzymes” posters category and received an award of $500. Raoul Wadhwa ’17 – originally from Portage, Mich., and now of Chicago – earned honorable mention recognition in “proteins and enzymes.”

The event is a joint meeting of six different societies including the American Society for Biochemistry and Molecular Biology (ASBMB) as well as societies for physiology, nutrition, pharmacology, pathology and anatomy.

Glass said the meeting was a great opportunity to find out what’s going on in science and to practice presenting research. She is a chemistry major who will pursue a Ph.D. starting this fall at Vanderbilt University.

Glass presented research associated with her Senior Individualized Project (SIP). She investigated enzymes in the human liver that help process medicines, work that may become relevant in predicting how individuals will respond to their medications.

In contrast to Glass, it might seem strange that Wadhwa, a math major, not only participated but earned honors in an event largely attended by chemistry and biology majors. However, this project – which also was his SIP – united his interdisciplinary interests in computer science, math, biology and chemistry.

Experimental Biology Meeting in Chicago
K students Christi Cho, Sarah Glass, Raoul Wadhwa, Cydney Martell, Jacqueline Mills, Sharat Kamath and Susmitha Narisetty joined professors Laura Furge and Regina Stevens-Truss at the annual Experimental Biology meeting in Chicago.

“Something like this could only happen at K,” he said, adding he owes a “thank you” to chemistry professors Regina Stevens-Truss and Laura Furge. Their guidance helped him inside and outside the lab, especially as they coached him in professionally presenting scientific research. “This would never have happened at a big university.”

Wadhwa described his research as still being a ways off from clinical application, although he was looking at a new class of potential drug therapies that in some ways are similar to antibiotics. He helped develop software used to predict the antibacterial potential of peptides being studied in Truss’s lab, work that could one day prove vital in this age of antibiotic resistance. Wadhwa will attend the Cleveland Clinic’s Lerner College of Medicine at Case Western University starting this fall.

Other K representatives included chemistry majors Christi Cho ’17, Jacqueline Mills ’18 and Cydney Martell ’19; along with biology majors Sharat Kamath ’18 and Susmitha Narisetty ’19. Cho also presented her SIP research and Narisetty presented results from her summer internship at South Dakota State University.

Science Forum Honors K Chemistry Major’s Research

Posted on

A Kalamazoo College chemistry major was one of just four students – and the only undergraduate – honored with recognition in January at an international science forum for a poster presentation of his research.

Science Forum Eric Thornburg and Jeff Bartz
Kalamazoo College chemistry major Eric Thornburg was one of just four students honored with recognition in January at an international science forum for a poster presentation of his research.

Eric Thornburg ’17, a Kalamazoo native, presented research on the photodissociation dynamics of nitrous acid, known through the molecular structure of HONO, at the Pacific Conference on Spectroscopy and Dynamics from Jan. 19-22 in Asilomar, Calif.

Spectroscopy measures light in terms of how materials emit, absorb or scatter it. In simple terms, the research, conducted over two years in Dow Science Center’s laser lab at K, furthers investigations into how the atmosphere attempts to reverse climate change as a result of nitrous acid and what humans might do about it.

The conference, touted by its website as one of the longest-running scientific conferences in the U.S., provides a forum for the dissemination and discussion of the latest results in chemistry and physics, and their confluence with biology.

Thornburg said this forum “provided a cool window into what my future holds. It’s great to be around people doing such a high level of work. I always hear about it, but rarely do we get to match faces and people with their experiments. In the future, (scientists) will have to collaborate more and more.”

Still, Thornburg didn’t realize he had been recognized in this way until after he returned to Kalamazoo. He and Chemistry Department Chair Jeffrey Bartz were reading the Journal of Physical Chemistry when they came across Thornburg’s name, mentioning the honor.

“It is really an honor that people saw my research and wanted to commend it,” Thornburg said. “I feel more prepared moving forward to contribute to conferences and the scientific community.”

Thornburg, who also minors in German, said K is an extraordinary place for math and science. He credits fellow students Marlon Gonzalez, Joyce Nguyen and Mia Orlando; recent K alumni Jeremy Lantis ’16 and Mara Birndorf ’16; and Bartz for integral assistance in performing the research.

“I’ve had a chance to work closely with Dr. Bartz, while sitting down and discussing how to implement this research,” Thornburg said. “He’d look at me and say, ‘What do you want to do?’ You don’t get that at a place that’s not like K.”

Thornburg will attend the University of Illinois this fall to seek his Ph.D. in chemistry.

 

Roads Back Home

Posted on
Alumni home for Homecoming 2015 reconnect with Professor Emeritus of Mathematics Jeff Smith.
Alumni home for Homecoming 2015 reconnect with Professor Emeritus of Mathematics Jeff Smith.

May the wind be at your back during your journey “home” to Homecoming 2016–October 14-16. Registration is open (with the schedule posted), and more than 300 persons plan to attend as of this writing (September 16). And why not! The autumn weekend is packed with events for all (and all ages).

Among the highlights:

Story Zoo at the Cavern Fire Circle (next to Stetson Chapel). Everyone has a favorite K story, or a S.O.B. in the closet. All alumni, students, faculty and staff are invited to stop by, enjoy a cup of hot chocolate and record your favorite K memory. All recorded stories will be sent to the College Archives as well as being available for future K publications. Individual or group stories are welcome!

The Alumni Association Awards Ceremony and Dessert Reception in Dalton Theatre. The event includes honors for distinguished achievement and distinguished service as well as new inductees into the athletics Hall of Fame. Of special note: Professor Emeritus of Biology Paul Sotherland will receive the Weimer K. Hicks Award.

And speaking of opportunities to reconnect with faculty, make sure Saturday’s departmental receptions make your calendar (see photo). It’s your chance to catch up with current and emeriti faculty in the Hicks Center.

It’s likely you know your alma mater has a new president (the institution’s 18th): Jorge Gonzalez. You can meet him and his wife (K alumnae Suzie (Martin) Gonzalez ’83) at an open house in the Kalamazoo College Field House Hornet Suite.

Pulitzer Prize for Poetry finalist Diane Seuss ’78 will read from her most recent collection of poems, Four-Legged Girl (Graywolf Press, 2015). Di is a longtime professor of English at K and her readings are unforgettable. And you’ll be able to purchase a copy of Four-Legged Girl at the Kalamazoo College Bookstore.

Professor of Chemistry Regina Stevens-Truss will discuss the ongoing Science and Social Justice project, work that has engaged some of the best minds in the country since 2011. Project collaborators include the Arcus Center for Social Justice Leadership, Harvard Medical School, the SENCER group and Massachusetts General Hospital. What social justice questions should be explicit in all scientific research and STEM education (Science, Technology, Engineering and Mathematics)? Help us come up with ideas.

On Sunday join Binney Girdler, associate professor of biology and director of the Lillian Anderson Arboretum, for a tour of “the Arb,” 140 acres of marsh, meadow, pine plantation and second-growth deciduous forest in Oshtemo Township. Not only is it a site for active research and ecological monitoring, it’s a grand place for a Sunday stroll. And it features the College’s brand new off-the-grid education pavilion named after Dr. H. Lewis Batts, Jr. ’43 and Jean M. Batts ’43. You gotta see it!

And these events are just a few of the highlights. Register now, and come home for Homecoming.

Summer Science Shared

Posted on

Summer ScienceScientific inquiry takes no summer break at Kalamazoo College, and a culmination of the summer’s work occurred at the Dow Science Center Mini Poster Session (August 26). In the chemistry department alone some 17 students worked in the laboratories of five chemistry faculty–Professors Bartz, Furge, Smith, Stevens-Truss and Williams. Those students include first-years, sophomores, juniors and seniors, many of the latter working on their Senior Individualized Projects. The mini poster session included 12 presenters explaining the science they had conducted during the summer. Quinton Colwell ’17 (in the red tie) is pictured discussing his poster, titled “Molecular Dynamics and Real-Life Drug Metabolism.” Molecular dynamics is the study of real life systems using computer models and simulations. Colwell’s work involved a relatively novel technique,biased molecular dynamics, which, he wrote, “brings an additional layer to computer simulations relevant to bench-top experiments. It has the potential to be a game-changer.” In addition to Colwell, other presenters included Sarah Glass ’17, Myles Truss ’17, Shreya Bahl ’17, Suma Alzouhayli ’17, and Blake Beauchamp ’17.

PUI Paragon

Posted on

Kalamazoo College Chemistry Professor Laura FurgeLaura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry, is a feature profile in a recent ASBMB Today, the professional development magazine of the American Society for Biochemistry and Molecular Biology. The article, titled “Working at a PUI,” focuses on the demands and rewards faculty face at “primarily undergraduate institutions.” Turns out rewards and demands may be so intertwined they’re indistinguishable.  For example, Furge’s academic wheelhouse is biochemistry, and yet she also teaches classes in organic chemistry and general chemistry and even a first-year writing seminar on cancer. The latter has become one of her favorite classes, a case in point of the demand-and-reward hybrid. Furge also notes that at PUIs the professor is the inter-generational “continuity of knowledge.” That vital function requires patience and broader skills on the part of the professor (demand) and makes a PUI professor-investigator-mentor like Furge the progenitor of generations of chemists and chemistry educators–think of Sarah in the Book of Genesis or Celeste in Edward P. Jones’ novel The Known World. That latter reference underscores another for Furge’s great strengths (one the PUI article misses): a fierce commitment to the liberal arts. The Known World was Kalamazoo College’s Summer Common Reading choice in 2007. Furge sits on the committee that selects these works. She also will begin her duties as associate provost at Kalamazoo College beginning July 1.

Professor Receives Lucasse Award for Teaching Excellence

Posted on
K Professor of Chemistry Regina Stevens-Truss
K Professor of Chemistry Regina Stevens-Truss

Kalamazoo College’s highest teaching honor is the Florence J. Lucasse Lectureship, awarded to a K faculty member in recognition of outstanding classroom teaching. The 2015-16 Lucasse Lectureship recipient is Professor of Chemistry Regina Stevens-Truss. And for this honor, she gets to deliver a lecture! Hear this outstanding teacher talk about her love of teaching – and celebrate her award – Thursday May 19, 4:00-5:30 p.m., in the Olmsted Room of Mandelle Hall.

“I love what I do every day, and I wake up every day looking forward to it,” says Professor Stevens-Truss. “I get to learn with young people and share my love of learning with them. For now, life doesn’t get better than this.”

Professor Stevens-Truss is a medicinal biochemist who has taught at K since 2000. She previously taught at the College of Pharmacy, University of Michigan. Her teaching responsibilities at K include Antibiotics: Global Health and Social Justice, Introductory Chemistry II, Biochemistry, and Principles of Medicinal Chemistry. Her research focuses on understanding the enzyme nitric oxide synthase and its involvement in Alzheimers’ disease, research she enjoys carrying out with her students.

She has also been involved in numerous outreach programs that have taken her and her students into the Greater Kalamazoo community and bringing the community to the K campus. These have included Art & Science of Medicine, a summer workshop for high school students intending to pursue a career in medicine, and Sisters in Science, a K student group supporting young girls who demonstrate an aptitude for math and science.

She currently helps lead the Science and Social Justice Project, an initiative of the Arcus Center for Social Justice Leadership (ACSJL) at Kalamazoo College and the Division of Medical Sciences at Harvard Medical School. The Project aims to study and promote the value of social justice in scientific education and research, and to identify, connect, and coordinate scholars doing science and social justice teaching and research.

Professor Stevens-Truss recently helped coordinate a three-day “Science and Social Justice Think Tank” at the ACSJL attended by professors, scholars, scientists, public health and environmental leaders from across the country working at the intersection of science and social justice, as well as stakeholders in academic institutions and scientific organizations who can speak to diversity in the STEM fields and to the changing landscape of science and society.

Professor Stevens-Truss earned a B.A. degree at Rutgers University and a Ph.D. degree at University of Toledo. She is a married mother of two children who enjoys photography, bowling, watching sports (“especially those involving my kids”), and watching CSI.

The Florence J. Lucasse Lectureship (for outstanding classroom teaching) and Fellowship (for outstanding achievement in creative work, research or publication) at Kalamazoo College were established in 1979. The awards were created to honor Florence J. Lucasse, alumna of Kalamazoo College Class of 1910, in recognition of her long and distinguished career and in response to the major unrestricted endowment gift given to the college in her will.