{"id":15933,"date":"2022-03-03T15:57:01","date_gmt":"2022-03-03T19:57:01","guid":{"rendered":"https:\/\/www.kzoo.edu\/news\/?p=15933"},"modified":"2022-03-25T12:52:49","modified_gmt":"2022-03-25T16:52:49","slug":"antibiotics-research","status":"publish","type":"post","link":"https:\/\/www.kzoo.edu\/news\/antibiotics-research\/","title":{"rendered":"Chemistry Student\u2019s Research Could Boost Antibiotics"},"content":{"rendered":"\n
\"Chemistry
Research conducted by Ola Bartolik ’22 at K has possible
implications for a new approach to antibiotics.<\/figcaption><\/figure><\/div>\n\n\n\n

Ola Bartolik \u201922 has an intrinsic curiosity about the importance chemistry plays in biology, specifically its role in neurodevelopment and neurological disease. Her high school interests in chemistry<\/a> led her to apply for Kalamazoo College\u2019s strong chemistry program, where she has been exploring the relationship between chemical structure and antimicrobial activity.<\/p>\n\n\n\n

Her research in the lab of Blakely Tresca, assistant professor of chemistry, has possible implications for the development of new antibiotics, which is an urgent need in today\u2019s medical field.<\/p>\n\n\n\n

\u201cThere is an antibiotic crisis because we\u2019re not finding new antibiotics and there is so much antibiotic resistance,\u201d Bartolik said. \u201cIt\u2019s becoming more and more of a problem as time goes by.\u201d<\/p>\n\n\n\n

Bartolik works with peptoids, which are man-made compounds similar to peptides, the building blocks of proteins. She is experimenting with adding different halogens to the peptoids to see how that changes the structure and if that plays a role in making the peptoid more anti-microbial.<\/p>\n\n\n\n

Two years ago, Tresca saw in Bartolik the first two things he looks for in students\u2014a spark of interest in organic chemistry and an excitement to make molecules in the lab\u2014and invited her to join his lab. There, she discovered that she loves thinking about how research can lead to new questions, solve problems and apply to daily life.<\/p>\n\n\n\n

\u201cShe has the drive to take ownership of a project and lead it in new directions,\u201d Tresca said. \u201cThe project she\u2019s working on right now is one she designed herself and has been leading, which is amazing even for a senior student.\u201d<\/p>\n\n\n\n

Bartolik is always prepared, able to work independently and thoughtful about science in both the lab and the classroom, Tresca said.<\/p>\n\n\n\n

\"\"
Ola Bartolik ’22 has worked in the research lab of Blakely Tresca,
assistant professor of chemistry, for two years. <\/figcaption><\/figure><\/div>\n\n\n\n

\u201cShe is almost always the first person to jump up with an answer, which shows how much she\u2019s thinking about what we\u2019re talking about in class,\u201d Tresca said. \u201cI appreciate that she\u2019s always willing to take a guess even if she\u2019s not sure she\u2019s right. They\u2019re not easy questions and they\u2019re things we don\u2019t necessarily know the answer to, so it\u2019s important to be comfortable with being uncomfortable and thinking through the science, which I really see with Ola.\u201d<\/p>\n\n\n\n

Tresca has been incredibly supportive in and out of the lab, Bartolik said, helping her apply to scholarships that have made her K experience possible.<\/p>\n\n\n\n

\u201cOla has taught me as much as I\u2019ve taught her, in terms of supporting students, helping them find opportunities and pursue those opportunities even if it\u2019s something they feel like is a stretch,\u201d Tresca said. \u201cOla is a fantastic person and a fantastic student. It\u2019s been amazing working with her and I\u2019m very excited to see what she does next.\u201d<\/p>\n\n\n\n

The support of both faculty and other students at K has been pivotal to Bartolik\u2019s success. Her experiences at an all-girls high school were empowering as well. <\/p>\n\n\n\n

Bartolik values the open curriculum at K that has allowed her to choose only courses that interested her, which have ranged from chemistry and biology to literature and philosophy. Even in a sophomore seminar named Poetry as Survival, Bartolik found connections to her science interests as she considered the relationship between coping with difficult life experiences and stress-induced triggers of disease. <\/p>\n\n\n\n

\u201cI always had this interest in neuroscience and how the brain works,\u201d she said. \u201cI was interested in the connection between chemistry and neuroscience and how it all works. I like looking at things on a smaller scale, a micro scale. If you change this one thing, what does it do to the whole system?\u201d<\/p>\n\n\n\n

For her Senior Integrated Project<\/a>, Bartolik worked in the lab of Paul Jenkins at the University of Michigan. She investigated an epilepsy associated mutation and how it may impact critical protein-protein interactions necessary for neuronal signaling. <\/p>\n\n\n\n

Bartolik will graduate this year with a bachelor\u2019s degree in chemistry with a biochemistry concentration and a psychology minor. She plans to attend graduate school to study neuroscience.<\/p>\n\n\n\n

She is interested in studying the effects of environment and mutations on brain development and pathways, and the relationship between problems in those pathways and neurodegenerative diseases.<\/p>\n\n\n\n

\u201cNeuroscience programs are really hard to get into, especially when you don\u2019t come from a neuroscience-heavy background with a lot of neuroscience research,\u201d Bartolik said. \u201cThe fact that I even have options, I think that tells you how incredible the chemistry department is here and how we\u2019re able to pursue things that don\u2019t have to necessarily relate directly to what we did at K.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Research by chemistry major Ola Bartolik \u201922 has possible implications for a new approach to antibiotics, which is an urgent need in today\u2019s medical field.<\/p>\n","protected":false},"author":252,"featured_media":15941,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[231],"tags":[53,50],"post_formats":[],"class_list":["post-15933","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-students","tag-biochemistry","tag-chemistry"],"yoast_head":"\r\nResearch By K Student Could Boost Antibiotics - News and Events<\/title>\r\n<meta name=\"description\" content=\"Research by chemistry major Ola Bartolik \u201922 has possible implications for a new approach to antibiotics, which is an urgent need in today\u2019s medical field.\" \/>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link 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