Dynamical Neuropharmacology: Development of a New Methodology

The concepts and methods of Systems Biology are being extended to neuropharmacology, to test and design drugs against neurological and psychiatric disorders. Computational modeling by integrating compartmental neural modeling technique and detailed kinetic description of pharmacological modulation of transmitter - receptor interaction is offered as a method to test the electrophysiological and behavioral effects of putative drugs.

I. Aradi and P. Érdi: Computational neuropharmacology:dynamical approaches in drug discovery. Trends in Pharmacological Sciences 27(5) (2006) 240-243.

B. Ujfalussy, T. Kiss, G. Orbán, WE. Hoffmann, P. Érdi and M. Hajós: Pharmacological and Computational Analysis of alpha-subunit Preferential GABA_A Positive Allosteric Modulators on the Rat Septo-Hippocampal Activity. Neuropharmacology 52(3) 733-743 (2007)

Érdi P, Kiss T, Tóth J, Ujfalussy B and Zalányi L: From systems biology to dynamical neuropharmacology: Proposal for a new methodology. IEE Proceedings in Systems Biology 153(4) 299-308 (2006)

T. Kiss and P. Érdi: From electric patterns to drugs: perspectives of computational neuroscience in drug design. BioSystems 86(1-3) 46-52 (2006)

P. Érdi and J. Tóth: Towards a dynamic neuropharmacology: Integrating network and receptor levels. In: Brain, Vision and Artifical Intelligence.M. De Gregorio, V. Di Maio, M. Frucci and C. Musio (eds). Lecture Notes in Computer Science 3704, Springer, Berlin Helidelberg 2005, pp. 1-14.