| James
A. Langeland
Upjohn Associate Professor of Life Sciences, Chair
of Biology Department
PhD University of Wisconsin; BA Kalamazoo College
Tel: 269-337-7010 FAX: 269-337-7251
Office: Dow 310 Email: jlange@kzoo.edu |
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Research Interests
My research lies at the interface of molecular genetics,
developmental biology, and evolution. In broad terms, I
am interested in genetic and developmental events that underlie
the evolution of animal form. I use organisms that occupy
key phylogenetic positions in the chordate lineage: amphioxus,
a cephalochordate that is the closest living relative to
vertebrates; lampreys, the simplest living vertebrates;
and sharks, the simplest vertebrates that have jaws and
limbs. By cloning and characterizing developmentally important
genes from these organisms, my lab is able to correlate
gene duplications and the acquisition of novel gene expression
domains with morphological innovations that occurred during
early vertebrate evolution.
Courses
BIOL 107 Introduction to Human Genetics
BIOL 112 Evolution and Genetics with Lab
BIOL 436 Advanced Genet5cs with Lab
BIOL 432 Developmental Biology with Lab
BIOL 466 Advanced Molecular Biology with Lab
Grants and Awards
WM Keck Foundation. $380,000 for the integration of teaching
and research.
National Science Foundation Grant #0110540; $320,000;
7/01-6/05
National Institutes of Health Grant # 1R15GM57803-01;
$100,000; 7/98-6/01
Selected Publications
(* denotes undergraduate
coauthor)
Langeland J.A., Holland L.Z., Chastain
R.A. and Holland N.D. 2006. An amphioxus LIM-homeobox gene,
AmphiLim1/5, expressed early in the invaginating organizer
region and later in differentiating cells of the kidney
and central nervous system. Int J Biol Sci 2:40-46.
Neidert, A.H*., Virupannavar, V.*, Hooker, G.W.* and Langeland,
J.A. 2001. Lamprey Dlx genes and Early
Vertebrate Evolution. Proceedings of theNational Academy
of Sciences 98:1665-1670.
Neidert, A.H.* Panopoulou, G., and Langeland,
J.A. 2000. Amphioxus goosecoid and the
Evolution of the Head Organizer and Prechordal Plate. Evolution
and Development 2(6):303-310.
Jackman, W. R., Jr.,Langeland, J.A. and
Kimmel, C.B. 2000. islet reveals segmentation in
the amphioxus hindbrain homolog. Developmental Biology 220:16-26.
Tomsa, J.M.* and Langeland, J.A. 1999.
Otx expression during lamprey embryogenesis provides insights
into the evolution of the vertebrate head and jaw. Developmental
Biology. 207:26-37.
Amores, A., Force, A., Yan, Y-L. Joly, L., Amemiya, C.,
Fritz, A., Ho, R.K., Langeland, J.A., Prince,
V., Wang, Y-L, Westerfield, M., Ekker, M. and Postlethwait,
J.H. 1998. Zebrafish hox Clusters and Vertebrate Genome
Evolution. Science. 282:1711-1714.
Langeland, J.A. Tomsa, J.M., William
R. Jackman, W. R., Jr. and Kimmel, C.B. 1998. An amphioxus
snail gene: Expression in paraxial mesoderm and neural plate
suggests a conserved role in patterning the chordate embryo.
Development, Genes, and Evolution. 208:569-577.
Langeland, J.A. 1998. Imaging immunolabelled
Drosophila embryos by confocal microscopy. In:
Methods in Molecular Biology, Humana Press, Totowa, NJ.
Langeland, J. A. and Kimmel, C. B. 1997.
Fishes. In: Embryology: Constructing the Embryo.
Sinauer Associates.
Carroll, S.B., Weatherbee, S. and Langeland, J.A.
1995. Homeotic genes and the regulation and evolution of
insect wing number. Nature. 375: 58-61.
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